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It has also been suggested that Trileptal, like other AEDs, may possibly be GABAergic in their effects, but more research is needed to determine the exact mechanics involved

41,48,49 It has been reported that up to 75% of their metabolism is unproductive due to proton leak (premature leakage of protons through the inner mitochondrial membrane not mediated by ATP synthase) which is staggering, given that insulin secretion occurs in an ATP-dependent manner

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If you are starting tirzepatide and suspect your GLP-1 related fatigue is excessive, consider whether suboptimal thyroid levels might be compounding the effect