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Peng PJ, Ho PS, Tsai CK, Huang SY, Liang CS

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An FDA decision on orforglipron is expected by spring 2026

Although the supplement is not FDA-approved, the official press release reads, "We spent years working with our medical advisory board to formulate Lemme GLP-1 Daily into the most effective and researched GLP-1 supplement on the market." According to Kardashian, "cutting-edge formulation uses both clinically studied and patented ingredients to increase GLP-1 levels in the body, naturally." Despite the claims, Kardashian's new supplement does not convince Lauren Harris-Pincus , MS, RDN, who told Page Six that this product is "unlikely" to work as semaglutide does

This can require counseling from nutritionists, since many patients tend to focus only on weight issues