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These include constrained tissue sizes, difficulty in cell retrieval for downstream analysis, and, most critically, a limited volume of effluent for comprehensive molecular profiling (e.g., proteomics, metabolomics), which is essential for biomarker discovery and mechanistic studies (54)
doi: 10.1186/s12935-022-02662-3 7 HebischMKlostermeierSWolfKBoccacciniARWolfSETanziREet al
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Hepatology 1997;25:148-53
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