Frequently examined in cellular signaling and structural protein research models
In this study, we determined the structural organisation of AIM/IgM by single particle cryo-EM, revealing the interactions between the two molecules and the mechanism by which AIM is stabilised in the serum by IgM
Common research applications include single-receptor pharmacology (semaglutide and liraglutide as GLP-1 reference agonists), dual-receptor comparison studies (tirzepatide for GIP/GLP-1, mazdutide and survodutide for GLP-1/glucagon), triple-receptor research (retatrutide), and multi-pathway combinations using amylin agonists alongside incretin agonists (cagri-sema, retatrutide+cagrilintide)
studies from 2020 demonstrate that chronic iron excess conditions induce an M2-like phenotype in THP-1 monocyte-derived macrophages, concurrently downregulating M1 markers (100)
and (3) Gene therapy approaches that correct the defective lysosomal cystine transport in parenchymal cells
