Additionally, some patients experience gastrointestinal side effects such as nausea, bloating, and reflux, all of which may indirectly stimulate the hiccup reflex arc
Also SGLT-2i, that promote urinary excretion of glucose blocking the SGLT-2 protein, have been demonstrated to stimulate cell proliferation and inhibit apoptosis in pancreatic islets, leading to a preservation of -cell mass and function in preclinical studies (Table 2) [78,79,80,81,82,83]
10.1016/S0165-6147(00)01502-9 117 HintonD
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Glucagon content in the samples was determined using a glucagon assay kit (Cisbio, 62CGLPEG)