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10.1161/CIRCULATIONAHA.107.739938 7 BeiroaD.ImbernonM.GallegoR.SenraA.HerranzD.VillarroyaF.et al (2014)

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The present invention further provides advantageous methods and uses that comprise: (a) administering to an animal or patient with a vascularized tumor a biologically effective amount of at least a first pharmaceutical composition comprising at least a first VEGFR2-blocking, human anti-VEGF antibody of the invention, or antigen binding fragment thereof, wherein the antibody or fragment has an enzymatic function, preferably wherein the antibody or fragment is operatively associated with, covalently linked to, or conjugated to, at least a first enzyme