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It is among the most studied next-generation incretin compounds, investigated for its effects on metabolic regulation, body composition, and glycemic control

In the primary Phase 2 clinical trial published in the New England Journal of Medicine (Jastreboff et al., 2023), retatrutide was studied across several dose levels, including: 1 mg (low dose) 4 mg (mid dose) 8 mg (higher dose) 12 mg (highest dose) These doses were administered as once-weekly subcutaneous injections

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Increase soluble and insoluble fiber slowly to 25 to 35 grams per day while raising fluid intake at the same time

Post: 38 yo female with PMH of HTN and Class I obesity presents for follow-up after 2 years on Zepbound 15mg