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Vitamin B12 is an essential component of a number of enzymes involved in normal metabolism

It slows gastric emptying, suppresses glucagon secretion, and promotes satiety through central nervous system actions

doi: 10.1002/hep.27857

Human clinical trials A pilot Phase I clinical trial conducted on three males by the College of Medicine , Pharmacology Department, University of Arizona in Tucson, Arizona published in 1996 reported that, "Melanotan II has tanning activity in humans given only 5 low doses every other day by subcutaneous injection." The side effects reported were mild nausea and a "stretching and yawning complex" that correlated with spontaneous penile erections