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Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1): A randomised, double-blind, placebo-controlled, phase 3 trial

Once the microneedles are inserted into the skin, the hydrogel swells due to the presence of interstitial fluid, and then, the drug is released from the microneedle into the dermis (Turner et al., 2023)

Summary: Small air bubbles in GLP-1 injection pens are not dangerous when administered subcutaneously and are commonly present due to manufacturing or storage, though removing larger bubbles ensures accurate dosing

Biosamples were collected if a separate informed consent form had been signed, in accordance with local ethical and regulatory requirements, as described in the original studies 20,21

This medication performs like the GLP-1 hormone that the gut releases in response to eating