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Naltrexone attenuated the increase in glutamate + glutamine to total N -acetylaspartate ratio during ketamine infusion compared to placebo ( F 1,253 = 4.83, P = 0.029) and also attenuated the reduction in Montgomerysberg Depression Rating Scale scores on day 1 (condition-by-time interaction, F 1,74 = 5.39, P = 0.023)

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