The STEP trials (the major trials of semaglutide for weight management) included detailed monitoring of psychiatric symptoms
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Shi A, Xie P, Nielsen LL, Skjth TV, He X, Haugaard SP (2021) Pharmacokinetics, safety and tolerability of once-weekly subcutaneous semaglutide in healthy Chinese subjects: a double-blind, phase 1, randomized controlled trial
Patients should consult their healthcare provider before initiating any new supplement regimen, particularly if they have multiple comorbidities, take multiple medications, or have a history of adverse reactions to supplements
This happens because the body detects high androgen levels and shuts down its own hormonal production through the hypothalamic-pituitary-gonadal axis