Across different modalitiesincluding caloric restriction, exercise-based interventions, pharmacological agents, and bariatric surgeryweight reduction has been shown to result in bone loss, reduced BMD, and compromised bone quality
For a typical subject with type 2 diabetes and a body weight of 85 kg, clearance was estimated to be 0.0348 L/h (95% CI 0.03270.0369 L/h) and the total volume of distribution was estimated to be 7.7 L ( V c + V p
Patients should be monitored closely during the initial dose escalation phase, then at least every 3-6 months once on the maintenance dose
If you realize your injection day has passed, administer your dose as soon as possiblewithin 2448 hours is ideal
Many patients achieve satisfactory results at 1.0mg, though some may increase to 1.7mg or the maximum 2.4mg weekly dose based on response and tolerability