Veterans Affairs databases found that GLP-1RA use was associated with reduced risks of major adverse cardiovascular events (MACE), stroke, heart failure, cardiac arrest, and thromboembolic disorders
Care Delays: Relying on patches might delay starting proper treatments for diabetes or obesity
Landmark preclinical studies using animal knockouts have demonstrated that GLP-1 receptors in the brain are capable of controlling food intake and body weight, in addition to the hypophagic effects of endogenous GLP1 via peripheral GLP1 receptors [33]
More specifically, both RCTs with paired liver biopsies showed improvement in hepatic steatosis and inflammation, but not fibrosis, after treatment with liraglutide or semaglutide
The anti-inflammatory effects alone make them worth considering for people with both obesity and depression, especially when inflammation appears to be a significant factor