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Animals were anesthetized with 25% urethane dissolved in distilled water (Sigma, U2500100 G) using intraperitoneal bolus injections (1.3 g/kg) divided into three separate doses

Always seek immediate medical attention

Common adverse reactions include gastrointestinal symptoms (which may lead to intestinal obstruction in severe cases), headache, migraine, dehydration, and erectile dysfunction

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The long-term cardiovascular safety and efficacy of glucagon-like peptide-1 (GLP-1) receptor agonists in high-risk cardiovascular populations: a systematic review and meta-analysis