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Mental Health Changes : Report worsening depression, suicidal ideation, or unusual changes in behavior

Higher doses produce greater weight loss, with the 12 mg dose consistently outperforming the 8 mg and 4 mg groups

Many patients achieve better glucose control on the combination than on either drug alone, but this can vary between individuals

It acts as both a GLP-1 and a glucose-dependent insulinotropic polypeptide (GIP) receptor agonist

As both treatments work through similar appetite-regulating pathways, many people have already adapted to this type of medication before making the change, which can help make the transition more manageable.