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When the skin captures UV radiation, keratinocytes produce -MSH (alpha-melanocyte stimulating hormone), a peptide hormone that binds to melanocytes and stimulates them to produce melanin , a pigment that absorbs UV and protects DNA from damage

Stacking both may intensify these effects in some individuals

Additionally, emerging data supports the complementary use of both drug classes, revealing additive benefits on cardiovascular and renal outcomes without increased toxicity