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These weight loss medications glucagon-like peptide-1 (GLP-1) receptor agonists were previously approved only for diabetes control, but several are now FDA approved to treat obesity, too

We also never observed any clustering by sex or disease status after comparable iterations of clustering attempts were performed using subdata sets created through various criteria using the comparable principal component analysis (PCA) method (not shown)

Another study, published in 2025, found similar results

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Extended half-life modeling due to reduced binding to IGF binding proteins (IGFBPs)