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However, persistent or excessive mechanical stress initiates a pathological cascade that activates these fibroblasts, transforming them into -smooth muscle actin (-SMA)-expressing myofibroblasts with enhanced ECM synthetic capabilities[53]

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[PubMed] [Google Scholar] 28.Adams JB, Romdalvik J, Ramanujam VM, Legator MS

The NIDDK advises prompt medical help for severe abdominal pain or cramping, vomit that contains blood or looks like coffee grounds, sudden sharp stomach pain, vomiting that continues for more than an hour, extreme weakness, fainting, breathing trouble, or fever