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Bock-Marquette and co-workers reported in Nature (2004) that Tb4 promotes cardiomyocyte survival post-myocardial-infarction in mice through PINCH/ILK/Akt signaling, and Smart and colleagues showed in 2007 that the same peptide mobilizes adult epicardial progenitor cells

Although the connection between the two isnt yet fully understood, research suggests that low levels of B-12 may be linked to an increased risk of depression, and that maintaining adequate levels could support better treatment outcomes