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initiation of a drug or a new diagnosis) in an insulin-only arm, but this is an area of future study

Incorporation of a trifluoromethyl group at the 6-position of the tetrahydropyran ring in omarigliptin (with a (2R, 3S, 5R, 6S) configuration) was found not only to enhance the pharmacokinetic profile in mice but also to maintain robust DPP-4 inhibitory activity

doi: 10.2116/analsci.17.1237

This distinction is critical when discussing risk with patients who already have hypertension, coronary artery disease, or heart failure

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