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Antioxidant effects after coffee enema or oral coffee consumption in healthy Thai male volunteers S Teekachunhatean N Tosri C Sangdee R Wongpoomchai W Ruangyuttikarn C Puaninta S Srichairatanakool We designed an open-label, randomized two-phase crossover study to investigate the antioxidant effects after single and multiple doses of a coffee enema versus coffee consumed orally

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If, however, you're designing a study specifically to test the local gut effects of peptides, then an oral formulation might be your test article, but you'd be doing so with the full understanding of its limitations