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[3] [5] Key drug interactions to be aware of: Anticoagulants (warfarin, direct oral anticoagulants) and other antiplatelet agentssignificantly increase bleeding risk Other NSAIDsavoid concomitant use due to additive gastrointestinal and bleeding risks SSRIs and serotonin-noradrenaline reuptake inhibitors (SNRIs)increase bleeding risk Systemic corticosteroidsincrease risk of gastrointestinal ulceration and bleeding Heavy alcohol consumptionincreases bleeding and gastric irritation Patients should be counselled about recognising signs of bleeding, such as black or tarry stools (melaena), vomiting blood (haematemesis), or unexplained bruising

This information will be helpful for their healthcare provider in making a thorough assessment

Patients with specific FTO rs9939609 genotypes, for example, may see accelerated early weight loss but require careful dose titration, while others with favorable GLP1R rs6923761 variants may achieve results at lower unit amounts

Pinch the skin, insert the needle at a 90-degree angle (or 45 degrees if you have very lean body composition), push the plunger slowly and steadily, hold for 5 to 10 seconds after the plunger is fully depressed, then withdraw and dispose of the syringe properly

Mild edema or water retention: Occasional, typically dose-related