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With an elimination half-life of approximately 5 days, tirzepatide (marketed as Mounjaro for type 2 diabetes and Zepbound for weight management) reaches steady-state concentrations after about 4 weeks of once-weekly dosing

A permanent, scarring type of hair loss, and an autoimmune type called alopecia areata, showed no clear link to the drugs

In the SURMOUNT 1 trial, tirzepatide 15 mg/wk with general nutritional instructions produced a 20.9 % reduction in body weight from baseline (versus 3.1 % with general nutrition instructions alone) [15], whereas in the SURMOUNT 3 trial, tirzepatide 10 or 15 mg/wk started after 12 weeks of intensive lifestyle intervention produced a 25 % reduction from baseline (versus 4.8 % with intensive lifestyle intervention alone) [170]

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Todos analizaron el compuesto de 3 episodios adversos cardiovasculares mayores (MACE), que inclua muerte cardiovascular, infarto de miocardio no mortal o ictus no mortal, excepto el estudio con lixisenatida que consider el MACE de 4 puntos, que inclua adems hospitalizacin por insuficiencia cardaca (tabla 1)5764