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The timing, frequency, and extent of senescent cell removal remain open questions (for example, when is it best to clear them? What is the rebound or regenerative consequence?)

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Accumulating evidence further demonstrates that in pSS models, reduced gut microbiome diversity and diminished production of microbiota-derived metabolites lead to decreased tolerogenic dendritic cells (DCs) and Th17/Treg imbalance, consequently promoting autoantibody accumulation and exacerbation of glandular inflammatory responses in pSS (203)

When reconstituted with bacteriostatic water and stored properly in a refrigerator (2-8C), IGF-1 LR3 remains stable and sterile for up to 28 days

It initiates cascades of physiological, biochemical and morphological changes that limit the productivity of plants 23