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Invest 130 , 14531460 (2020)

It is important to note that whilst many patients experience blood pressure reductions, individual responses vary considerably

The peptide performs most of its function by binding to Ghrelin receptors localized in the hypothalamus, which further stimulates the pituitary gland to secrete additional growth hormone

This can lead to shifts in body composition that the scale doesnt reflect

However, hypothalamic damage or disrupted hypothalamic development in humans results in hyperphagia and reduced energy expenditure, implying that the hypothalamus is likely to play a similar role in the physiology of human satiety and energy regulation