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HFpEF represents a heterogeneous clinical syndrome characterized by limited effective treatment options due to its complex pathophysiology

While cross-trial comparisons are limited by differences in patient populations and study duration, the head-to-head percentage is clear: Retatrutides triple-action mechanism has generated the highest average weight loss percentage reported to date for any single pharmacological agent

Trbiska-Stryjewska A, Wakula M, Chmielarczyk M, Grzybowska EA (1870) 2023 HAX1 A versatile, intrinsically disordered regulatory protein. Biochimica et Biophysica Acta BBA Mol Cell Res 7:119538

This helps maintain steady hormone levels and further reduces the likelihood of side effects

20 g of propidium iodide (PI) was added for 30 min and microscopic images were taken using Keyence Fluorescent Microscope BZ-X800