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This culminates in a combined insult of oxidative stress, excessive autophagy, and inflammatory damage in the liver

By week 4 the appetite control wasn't as strong so I decided to take several days off, once I restarted not only was the appetite control back, but it was stronger too

In turn these define optimal therapy choice, for example, a high BMI requires a more potent anti-obesity therapy, e.g., a triple hormone-receptor agonist targeting GLP-1, GIP and glucagon, to achieve initial weight loss

Furthermore, the emergence of novel agents such as tirzepatide, dual and triple hormonal agonists, expands the therapeutic landscape for managing T2DM effectively

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