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10.3389/fphar.2020.00291 66 LiaoH.YeJ.GaoL.LiuY

Strengths and weaknesses The strengths of this substudy include the methods and design of SUSTAIN 8, a double-blind randomised clinical trial with a global population, relatively long treatment period of 52 weeks, and relevant head-to-head comparison with a glucose-lowering medication with demonstrated efficacy in type 2 diabetes

Initial investigations primarily focused on histone modifications, particularly at key sites such as H3K9, H3K18, H4K5, H4K8, and H4K12

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No randomization was used to allocate animals to experimental groups, and investigators were not blinded to the group allocation during experiments or outcome assessments