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indeed, it has been shown that mice genetically lacking miR-378 and miR-378* are resistant to high-fat-diet-induced obesity and display enhanced mitochondrial FA metabolism and elevated oxidative capacity of insulin-target tissue 90

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GIP/GLP-1s The newest class of drugs that treat both type 2 diabetes and obesity work with both of the main digestive hormones that tell your body to make insulin: GLP-1 and glucose-dependent insulinotropic polypeptide (GIP)