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Clin Pharmacol Ther 31:151156 Miners JO, Penhall R, Robson RA, Birkett DJ (1988) Comparison of paracetamol metabolism in young adult and elderly males

It means the relative impact may be less dramatic than it was during the initial months

Utilizing gradual dose titration protocols, starting with lower doses and incrementally increasing over several weeks, significantly reduces the incidence and severity of these side effects