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doi: 10.1016/j.prp.2023.154538 514 KaushikMTikuA

Researchers observed notable increases of nearly 198% in 3-HB and 95% in the C2/C0 ratio at the 12 mg dose in these participants

hospitalization required Maintenance of Remission: Immunomodulators (azathioprine, 6-MP, methotrexate) for steroid-dependent or frequently-relapsing disease Biologic monotherapy or combination therapy (biologic + immunomodulator) for moderate-to-severe disease Step-up or top-down approach based on disease severity, patient risk factors, and prior therapy Biologic Therapy Targets: TNF-: Infliximab (IV), adalimumab (SC), certolizumab pegol (SC) IL-12/23: Ustekinumab (IV induction, SC maintenance) Integrin: Vedolizumab (IV) IL-23: Risankizumab (IV induction, SC maintenance) JAK inhibition: Upadacitinib (oral) Surgical Management Surgery is indicated in approximately 7080% of patients with Crohns disease over their lifetime, per StatPearls

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These challenges arise mainly from CSC heterogeneity and plasticity, the lack of reliable biomarkers, and the complex interactions between CSCs and the TME