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Figure 5 where dy/dp represents sensitivity, M (1.2 p )[ t ] and M (0.8 p )[ t ] are the metabolite concentrations at the time point t in simulation with the parameter p value multiplied by 1.2 and 0.8 respectively, M ( p )[ t ] is the metabolite concentration at the time point t in the original simulation (no parameter variation), and dp is the change in parameter value from its value in the original model