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Human gammadelta T lymphocytes induce robust NK cell-mediated antitumor cytotoxicity through CD137 engagement

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These observations indicate that IGF-1 LR3 may exhibit superior anabolic actions under specific experimental conditions, although this is not uniformly seen across all measured parameters

Li et al 153 recently found that ADH4 expression in HCC correlated negatively with the infiltration of immune cells (e.g., CD19+ B cells, CD68+ macrophages, and CD4+ T cells) and the expression of immune checkpoint proteins (e.g., cytotoxic T lymphocyteassociated antigen-4, programmed cell death protein 1, lymphocyte activation gene-3, and vascular endothelial growth factor B), suggesting that ADH4 is a potential target for immunotherapeutic intervention for HCC