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The expressions of SIRT7 and SDC1 are decreased in DKD patients, diabetic renal injury rat model, and HG-treated HGECs, accompanied by collagen deposition and interstitial fibrosis

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Also, modifiers of poly GR 100 toxicity identified from an unbiased genome-wide nonessential yeast gene knockout study revealed dysregulation of mitochondrial and NADPH related metabolic pathways (Chai and Gitler, 2018)

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