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Although these data appear to conflict with our observation that tirzepatide stimulates alpha cell activity, it is important to note that the metabolic profile of the subjects in the tirzepatide arm improved dramatically during the 28-week period, complicating interpretations

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Persistent dark urine despite hydration, tea-coloured urine, or accompanying jaundice requires prompt medical evaluation to exclude gallbladder disease, hepatobiliary disorders, or acute kidney injury

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The other senior author is Markus Stoffel, MD, PhD, professor of metabolic diseases at the Institute of Molecular Health Sciences, ETH Zurich in Switzerland