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These pyrophosphate analogs antagonize the ability of transketolase in vitro [113] In diabetes mellitus type 2 experimental model, the role of transketolase in the reductive pentose pathway and its activation by administration of lipid soluble thiamine derivative benfotiamine is well documented and undeniable [114] and further clinical research is ongoing

434 Over time, this selective pressure enriches resistant CSC clones, leading to tumor recurrence and therapy failure

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[2] Supplements are commonly taken orally but may be administered via intramuscular injection to treat deficiencies