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However, most pivotal trials were designed to evaluate: Weight loss Glycaemic control Cardiovascular outcomes Safety and tolerability Micronutrient status was rarely a primary or secondary endpoint

Of note, consistent with post-translational mTOR inhibition by rapamycin, MYC was significantly upregulated, yet MYC targets were significantly downregulated (Fig

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Weight loss was significantly greater with liraglutide than placebo for all primary endpoints