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Individuals with moderate to severe diabetic retinopathy, long diabetes duration, or poor prior glycaemic control face elevated risk during initial treatment months

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With the brush border membrane directly exposed to drugs inhibiting thiamine influx through SLC19A3, and nutrient efflux through the basolateral membrane to satisfy permanent systemic demands for thiamine, the steady-state concentration of thiamine in the gut epithelium may be decreased

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91 SahathevanS.KarupaiahT.KhorB.Sadu SinghB.Mat DaudZ.FiaccadoriE.et al (2021)