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The mechanism(s) by which GLP-1RAs would cause NAION is also unclear, particularly as GLP-1RAs are associated with neuroprotective properties and reductions in ischemic risk (96), but it has been hypothesized to be related, like the exacerbation of retinopathy, to rapid improvements in glycemic control (Figure 3)

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Furthermore, systemic activation of NLRP3 inflammasome promotes the accumulation of -synuclein and degeneration of dopaminergic neurons in the SN (Fan et al