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The GLP-1 crunch
While significant progress has been made in understanding how the central nervous system processes individual states such as fear 4 , pain 5,6 , hunger 5 , and thirst 6 , the mechanisms by which the brain hierarchically organizes competing survival demands remain poorly understood
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doi: 10.1038/nri1937
In pregnant rabbits given 0.2, 2, 22, 156, or 260 mcg/kg/day exenatide during fetal organogenesis, irregular fetal skeletal ossifications were observed at 2 mcg/kg/day, a dose yielding systemic exposure up to 12-times the human exposure from the MRHD of BYETTA based on AUC comparison
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