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Thus, the loss of FXa-dependent PAR2 signaling in PAR2-G37I mice and genetic deletion of FX in myeloid cells promoted a concordant macrophage inflammatory phenotype

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First, the historical absence of a globally unified definition of rare diseases constrained our study scope to the top ten rare diseases with the highest R&D activity, which may not fully represent the broader spectrum of rare disease research

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This can be important even if you dont have symptoms, because sometimes the effects of hormones are subtle