Osthole attenuated C10:2-induced pulmonary vascular remodeling by downregulating proliferation markers (PCNA, cyclin A, CDK2), modulating apoptosis markers (Caspase-3, Bax, Bcl-2), inhibiting migration-related proteins (MMP2, MMP9, TGF-), and reducing AMPK-1 and ROS overaccumulation as well as HSP47 expression
Yamamoto, Hiroshi
Confirmed at 28 days A follow-up 28-day study (Babula et al., 2024) extended the finding: 5-Amino-1MQ dose-dependently limited body weight and fat mass gain without changing food intake, and it improved liver markers in obese mice
Conversely, the AST + FPN groups IL-1 , IL-6, and TNF- levels returned to normal following AST treatment, possibly related to ASTs anti-inflammatory properties 16,25,61
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