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One of the most pivotal studies supporting the FDA approval of semaglutide for chronic weight management is the STEP 1 clinical trial

**Potential Risk of Pancreatitis**: While rare, there have been reports of pancreatitis in some patients taking these medications

It is important for anyone taking semaglutide to be aware of how their body responds and take steps to keep their digestion healthy

The commenters specifically highlighted the proposed measures MIPS Q220: Functional Status Change for Patients With Low Back Impairments and MIPS Q503: Patient Activation Measure (PAM) as proprietary measures and recommended that CMS remove these measures from the ASM low back pain quality measure set unless all PRO-PM items, scoring rules, and risk-adjustment models are fully disclosed and publicly available

Intramuscular injections generally cost $50-150 per shot, administered 1-2 times weekly initially, then monthly for maintenance