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More generally, while NO has been implicated in mechanisms of intoxication and other aspects of addiction for specific drugs, including a likely role in hyperactivity induced by dopaminergic stimulants like cocaine and amphetamines (Tayfun Uzbay and Oglesby, 2001), NO is most consistently involved in neural mechanisms underlying withdrawal (i.e., sequelae of plastic changes in neural circuits that occur during drug-associated learning)

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