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It is, of course, difficult to simply control for what may be deeply pervasive selection effects that elude straightforward quantification, and blood donation carries with it its own risks and adverse effects, ranging from simple skin bruising to temporary dampening of the immune system due to systemic stress
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In fact, the mean number of concomitant glucose-lowering agents and total daily insulin doses decreased during follow-up
M., Schreiber, E., Fogel, H., et al
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