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Materials and methods: Pancreatic islets were isolated from 8 weeks old overweight and hyperglycemic db/db and lean wild type (WT) mice

These physiological responses can accelerate the aging of the skin by breaking down collagen and elastin, leading to the formation of wrinkles and fine lines

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Key objectives of pharmacovigilance in clinical trials include: Early identification of adverse drug reactions Continuous monitoring of benefit-risk balance Compliance with global regulatory requirements Protection of trial participants Supporting regulatory decision-making Effective pharmacovigilance systems ensure that safety concerns are detected promptly and that appropriate regulatory actions can be taken when necessary

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