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The landmark studies that established Dihexa's cognitive enhancement properties used daily dosing to demonstrate proof-of-concept, not because frequency optimization studies determined daily was superior

10.4103/2221-1691.380562 129 ShibataS.TakahashiK.YanoS.HaradaM.SaitoH.TamuraY.et al (1987)

The review found only four trials comparing CHCs with placebo, of which only one followed patients for over a year (238), whilst the remaining three followed weight changes over only 6-9 cycles

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