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They mimicked a gut hormone, GLP-1, that modulates insulin, glucagon, and gastric emptying
When calcium levels decline (whether from inadequate intake, increased losses, or accelerated bone turnover), parathyroid hormone (PTH) activates as an emergency response, defending serum calcium through bone mobilization, reduced urinary loss, and increased intestinal absorption
This is particularly beneficial for overweight individuals with Type 2 diabetes, as losing weight can improve overall health and insulin sensitivity
Indeed, nine patients that were originally reported as LCAD-deficient, diagnosed by a reduction in palmitoyl-CoA degradation [7], were reported to have normal LCAD protein levels on western blot [8] and upon subsequent analyses many were in fact VLCAD-deficient [9]
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