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It is primarily caused by autoimmune destruction of the gastric parietal cells, leading to a deficiency in Intrinsic Factor and, consequently, a failure to absorb vitamin B12

Move to 0.5 mg for another four weeks

Reasons for these changes include: Shifts in hunger hormones Changes in gutbrain signaling Altered sleep patterns A faster or slower adjustment of the nervous system to new eating habits Most mood changes improve as the body adjusts to the medication

An interesting mechanism of local balancing of synaptic changes has been described in inhibitory neurons from basolateral amygdala

It noted depression as a potential side effect but did not focus explicitly on this correlation