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Who should consider tirzepatide with B12 and who should avoid it Ideal candidates for tirzepatide with B12 include adults with obesity (BMI 30) or overweight with comorbidities (BMI 27 with conditions like type 2 diabetes, hypertension, or dyslipidemia)

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Because these mechanisms reinforce one another, the overall metabolic effect can appear robust even if any single component varies, which is another reason a clean, isolated read on the gastric-emptying contribution is so hard to obtain from combination-drug outcome data

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